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Breast Cancer, Omega 3 And Cbd!
Posted 09 October 2012 - 08:35 AM
Nutr Cancer. 2002;42(2):180-5.[/font]
Long-chain n-3-to-n-6 polyunsaturated fatty acid ratios in breast adipose tissue from women with and without breast cancer.
Bagga D, Anders KH, Wang HJ, Glaspy JA.
[Division of Hematology-Oncology, Department of Medicine, University of California, Los Angeles School of Medicine, Los Angeles, CA 90095, USA.
[font="""]Animal studies suggest that dietary polyunsaturated fatty acids (PUFAs) of the n-6 class, found in corn and safflower oils, may be precursors of intermediates involved in the development of mammary tumors, whereas long-chain (LC) n-3 PUFAs, found in fish oil, can inhibit these effects. This case-control study was designed to examine the relationship between the PUFA composition of breast adipose tissue and the risk of breast cancer. Using fatty acid levels in breast adipose tissue as a biomarker of past qualitative dietary intake of fatty acids, we examined the hypothesis that breast cancer risk is negatively associated with specific LC n-3 PUFAs (eicosapentaenoic acid and docosahexaenoic acid) and positively associated with n-6 PUFAs (linoleic acid and arachidonic acid). Breast adipose tissue was collected from 73 breast cancer patients and 74 controls with macromastia. The fatty acid levels were determined by gas-liquid chromatography. A logistic regression model was used to obtain odds ratio estimates while adjusting for age. The age-adjusted n-6 PUFA (linoleic acid and arachidonic acid) content was significantly higher in cases than in controls (P = 0.02). There was a trend in the age-adjusted data suggesting that, at a given level of n-6 PUFA, LC n-3 PUFAs (eicosapentaenoic acid and docosahexaenoic acid) may have a protective effect (P = 0.06). A similar inverse relationship was observed with LC n-3-to-n-6 ratio when the data were adjusted for age (P = 0.09). We conclude that total n-6 PUFAs may be contributing to the high risk of breast cancer in the United States and that LC n-3 PUFAs, derived from fish oils, may have a protective effect.
Translation- Too much Omega 6, found in corn and safflower oils, may be involved in forming breast cancer tumors, where Omega 3, found in fish oil or flax seed oil can inhibit this! We looked at the relationship between levels of Omega 3 and 6, and the risk of breast cancer. We looked at the levels of fatty acids to check the Omega levels in breast fat, to see if there was a protective effect for Omega 3, and a pro-cancer effect for Omega 6. Tissue samples were gathered from 73 women with breast cancer and 74 without breast cancer, but who had abnormal breast growth. We used [font="""]gas-liquid chromatography to check the levels. We figured the odds and adjusted for age. The women who had more Omega 3 seemed to be protected against breast cancer. While the ones who had more Omega 6, seemed to increase the risk of breast cancer. We think that the high levels of Omega 6 in the “average American diet” may be contributing to the risk of breast cancer, while Omega 3 from fish oils, may have a protective effect![/font]
Biochem Biophys Res Commun. 2010 Nov 26;402(4):602-7. Epub 2010 Oct 28
Fish oil prevents breast cancer cell metastasis to bone.
Mandal CC, Ghosh-Choudhury T, Yoneda T, Choudhury GG, Ghosh-Choudhury N.
Department of Pathology, University of Texas Health Science Center at San Antonio, Texas, USA
The data derived from epidemiological and animal models confirm a beneficial effect of fish oil (rich in ω-3 polyunsaturated fatty acids) in the amelioration of tumor growth and progression, including breast cancer. The breast cancer patients often develop bone metastasis evidenced by osteolytic lesions, leading to severe pain and bone fracture. Using a mouse model of MDA-MB-231 human breast cancer cell metastasis to bone, here we show that fish oil diet enriched in DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid) prevents the formation of osteolytic lesions in bone, indicating suppression of cancer cell metastasis to bone. These results are supported by our data showing both DHA and EPA significantly attenuate the migration/invasion of MDA-MB-231 breast cancer cells in culture. The mechanism that limits breast cancer cells to selective metastasis to bone remains hitherto unexplored. Aberrant increased expression of CD44 is associated with generation of cancer stem cells, which contribute to metastasis of breast cancer cells. We demonstrate that DHA and EPA significantly inhibit the expression of CD44 protein and mRNA by a transcriptional mechanism. Furthermore, we show markedly reduced levels of CD44 mRNA and protein in the tumors of mice, which were fed fish oil diet than those in control diet. Our data provide the first evidence for a salutary effect of fish oil on breast cancer metastasis to bone. Our results identify a novel function of the fish oil active components, DHA and EPA, which target the cell-intrinsic pro-metastatic molecule CD44 to inhibit migration/invasion.[/font]
Translation - We confirm that fish oil slows the growth and spread of cancer, including breast cancer. Breast cancer patients often have their cancer spread to their bones causing great pain and broken bones. We used mice to show that fish oil prevents the formation of the lesions that precede actual bone cancer. This was further supported by test tube studies showing that Omega 3 (DHA & EPA) keep breast cancer cells from spreading. We don’t know how this works, but we note that high levels of a protein, CD44, is associated with the spread of breast cancer. Omega 3 significantly lowers the levels of CD44. Mice who got Omega 3 had way less CD44 than mice on a regular diet. Our data shows that fish oil helps to prevent the spread of breast cancer to bone. Our results show that it is the Omega 3 from fish oil that lowers the level of CD44 and inhibits the spread of breast cancer by targeting CD44.
And some high CBD marijuana (that won't get you stoned) is also in order!
Marijuana compound may stop deadly cancer metastasis
We've known about medical applications of cannabis (or marijuana) for years, but the research findings of two scientists studying it have the potential to change the deadliness of cancer forever. A cannabis compound known as cannabidiol can stop metastasis in many types of aggressive cancers, found the researchers from California Pacific Medical Center in San Francisco.
Cannabidiol (CBD) is a non-toxic, non-psychoactive chemical found in the cannabis plant, that had already been effective in relieving convulsion, inflammation, anxiety and nausea, and in treating schizophrenia and dystonia. For the 2007 study, Sean McAllister, who was specifically studying the effects of cannabidiol, collaborated with Pierre Desprez, who for the last 10 years has been studying the ID-1 gene in cancer that causes metastasis.
Metastasis is when a cancer spreads from the primary tumor area to other parts of the body, typically using the bloodstream or lymphatic system, and is one of the hallmarks of a tumor becoming malignant.
"What we found was that his Cannabidiol could essentially 'turn off' the ID-1," Desprez told The Huffington Post. "We likely would not have found this on our own," he added.
"That's why collaboration is so essential to scientific discovery."
Since publishing their study, the two went on to study the effect of CBD on other cancers.
"Now we've found that Cannabidiol works with many kinds of aggressive cancers — brain, prostate — any kind in which these high levels of ID-1 are present." said Desprez.
Since CBD has already been safely used by people for other ailments, the two hope that clinical trials can begin soon. However, treating cancer metastasis in this way requires more than just lighting up.
"We used injections in the animal testing and are also testing pills," he said. "But you could never get enough cannabidiol for it to be effective just from smoking."*
The two are now working on synthesizing the cannabidiol in the lab, rather than using samples from the plant, which should not only make it more potent, but also hopefully clear any obstacles at getting the drug approved.
* And I wouldn't be too sure about not being able to get enough CBD- there are new strains of high CBD cannabis and we know how to make RSO to concentrate the CBD!
Now print these up and show them to your mother, sisters, aunts and cousins!
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Posted 09 October 2012 - 09:14 AM
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Posted 09 October 2012 - 12:08 PM
Health and happiness
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