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Chemo 'undermines Itself' Through Rogue Response


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#1 DEBhasgrn

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Posted 06 August 2012 - 04:41 AM

5 August 2012

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Chemotherapy can undermine itself by causing a rogue response in healthy cells, which could explain why people become resistant, a study suggests.

The treatment loses effectiveness for a significant number of patients with secondary cancers.
Writing in Nature Medicine, US experts said chemo causes wound-healing cells around tumours to make a protein that helps the cancer resist treatment.

A UK expert said the next step would be to find a way to block this effect.
Around 90% of patients with solid cancers, such as breast, prostate, lung and colon, that spread - metastatic disease - develop resistance to chemotherapy.

Treatment is usually given at intervals, so that the body is not overwhelmed by its toxicity.
But that allows time for tumour cells to recover and develop resistance.
In this study, by researchers at the Fred Hutchinson Cancer Research Center in Seattle looked at fibroblast cells, which normally play a critical role in wound healing and the production of collagen, the main component of connective tissue such as tendons.

But chemotherapy causes DNA damage that causes the fibroblasts to produce up to 30 times more of a protein called WNT16B than they should.
The protein fuels cancer cells to grow and invade surrounding tissue - and to resist chemotherapy.
Success v failure

It was already known that the protein was involved in the development of cancers - but not in treatment resistance.

The researchers hope their findings will help find a way to stop this response, and improve the effectiveness of therapy.

Peter Nelson, who led the research, said: "Cancer therapies are increasingly evolving to be very specific, targeting key molecular engines that drive the cancer rather than more generic vulnerabilities, such as damaging DNA.

"Our findings indicate that the tumour microenvironment also can influence the success or failure of these more precise therapies."

Prof Fran Balkwill, a Cancer Research UK expert on the microenvironment around tumours, said: "This work fits with other research showing that cancer treatments don't just affect cancer cells, but can also target cells in and around tumours.

"Sometimes this can be good - for instance, chemotherapy can stimulate surrounding healthy immune cells to attack tumours.

"But this work confirms that healthy cells surrounding the tumour can also help the tumour to become resistant to treatment.

"The next step is to find ways to target these resistance mechanisms to help make chemotherapy more effective."
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#2 teddys head

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Posted 06 August 2012 - 09:59 AM

interesting stuff our Debs :)

Health and happiness
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#3 froggymountain

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Posted 06 August 2012 - 05:56 PM

Our friend has melenoma. She has gone through three chemo treatments and several surgeries. Now her 4th chemo treatment had a special side-effect - ANOTHER TYPE OF SKIN CANCER

TREATMENTS KNOWN TO CURE MELANOMA'S
- Gerson Therapy
- Intravenous Vitamin C in Megadose
- Cannabis Oil and juiced cannabis leaf


Here 4th chemo from a pill - OK now for the story straight from the manufacturer

ZELBORAF may cause a type of skin cancer called cutaneous squamous cell carcinoma

Possible serious side effects of ZELBORAF include severe allergic reactions, severe skin reactions, changes in the electrical activity of your heart called QT prolongation, which can potentially be life-threatening, abnormal liver function tests, eye problems, or new melanoma lesions

While taking ZELBORAF, you should avoid going out in the sun.

Common side effects of ZELBORAF include joint pain, rash, hair loss, tiredness, sunburn or sun sensitivity, nausea, itching, or warts.

These are not all of the possible side effects of ZELBORAF

……… and one would submit to this treatment why?????


Use of ZELBORAF and Important Side Effect Information

This information does not take the place of talking to your doctor about your medical condition or your treatment with ZELBORAF.
ZELBORAF is a prescription medicine used to treat a type of skin cancer called melanoma, that has spread to other parts of the body or cannot be removed by surgery, and has a certain type of abnormal "BRAF" gene.

ZELBORAF may cause a type of skin cancer called cutaneous squamous cell carcinoma (cuSCC). CuSCC usually does not spread to other parts of the body. Check your skin and tell your doctor about skin changes including a new wart, a sore or bump that bleeds or does not heal, or a mole that changes size or color.

While taking ZELBORAF, you should avoid going out in the sun. When you go outside, wear clothes that protect your skin, including head, face, hands, arms, and legs. Use lip balm and a broad-spectrum sunscreen with SPF 30 or higher.

Possible serious side effects of ZELBORAF include severe allergic reactions, severe skin reactions, changes in the electrical activity of your heart called QT prolongation, which can potentially be life-threatening, abnormal liver function tests, eye problems, or new melanoma lesions.

Common side effects of ZELBORAF include joint pain, rash, hair loss, tiredness, sunburn or sun sensitivity, nausea, itching, or warts.

These are not all of the possible side effects of ZELBORAF. Tell your doctor if you have any side effect that bothers you or does not go away. For more information about side effects, ask your doctor or pharmacist.



http://www.zelboraf.com/?cid=zel_we_F001067_P000517&utm_source=google&utm_medium=cpc&utm_term=zelboraf&utm_campaign=Branded&gclid=CNfVmqDLm6wCFQUKKgodqkEE3w
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#4 DEBhasgrn

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Posted 07 August 2012 - 05:09 AM

Our friend has melenoma. She has gone through three chemo treatments and several surgeries. Now her 4th chemo treatment had a special side-effect - ANOTHER TYPE OF SKIN CANCER

TREATMENTS KNOWN TO CURE MELANOMA'S
- Gerson Therapy
- Intravenous Vitamin C in Megadose
- Cannabis Oil and juiced cannabis leaf


Here 4th chemo from a pill - OK now for the story straight from the manufacturer

ZELBORAF may cause a type of skin cancer called cutaneous squamous cell carcinoma

Possible serious side effects of ZELBORAF include severe allergic reactions, severe skin reactions, changes in the electrical activity of your heart called QT prolongation, which can potentially be life-threatening, abnormal liver function tests, eye problems, or new melanoma lesions

While taking ZELBORAF, you should avoid going out in the sun.

Common side effects of ZELBORAF include joint pain, rash, hair loss, tiredness, sunburn or sun sensitivity, nausea, itching, or warts.

These are not all of the possible side effects of ZELBORAF

……… and one would submit to this treatment why?????


Use of ZELBORAF and Important Side Effect Information

This information does not take the place of talking to your doctor about your medical condition or your treatment with ZELBORAF.
ZELBORAF is a prescription medicine used to treat a type of skin cancer called melanoma, that has spread to other parts of the body or cannot be removed by surgery, and has a certain type of abnormal "BRAF" gene.

ZELBORAF may cause a type of skin cancer called cutaneous squamous cell carcinoma (cuSCC). CuSCC usually does not spread to other parts of the body. Check your skin and tell your doctor about skin changes including a new wart, a sore or bump that bleeds or does not heal, or a mole that changes size or color.

While taking ZELBORAF, you should avoid going out in the sun. When you go outside, wear clothes that protect your skin, including head, face, hands, arms, and legs. Use lip balm and a broad-spectrum sunscreen with SPF 30 or higher.

Possible serious side effects of ZELBORAF include severe allergic reactions, severe skin reactions, changes in the electrical activity of your heart called QT prolongation, which can potentially be life-threatening, abnormal liver function tests, eye problems, or new melanoma lesions.

Common side effects of ZELBORAF include joint pain, rash, hair loss, tiredness, sunburn or sun sensitivity, nausea, itching, or warts.

These are not all of the possible side effects of ZELBORAF. Tell your doctor if you have any side effect that bothers you or does not go away. For more information about side effects, ask your doctor or pharmacist.



http://www.zelboraf.com/?cid=zel_we_F001067_P000517&utm_source=google&utm_medium=cpc&utm_term=zelboraf&utm_campaign=Branded&gclid=CNfVmqDLm6wCFQUKKgodqkEE3w


Hi froggyMountain, Hows it going for you?? I want to thank you for all of your helpful information that you always share with us,, I might not always agree, but isn't that what it's all about sometimes, We learn from each other, We are also able to get to know one another too,, and it's nice getting to know You...

The chemo and radiation scares the heck out of me,,I had known that the chemo and radiations was also killing the good cells, and I say it is about time that they are admitting it.. I have seen so much cancer around me here at home and on our GP site,, I have witnessed people put themselves through the chemo treatments right up till the end, They hang on to any hope there might be, big or small,, I say I don't understand but,, I also am not walking in their shoes,,, BLESSINGS TO THEM ALL!!!!

Peace, Happiness and always Good Health!!!!
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#5 froggymountain

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Posted 12 August 2012 - 10:28 AM

CHEMOTHERAPY INDUCES RESISTANCE IN CANCERS


Study Links Cancer’s Ability to Spread with Chemotherapy Resistance

3 comments
By Julie Grisham, MS, Science Writer/Editor | Friday, July 6, 2012

Doctors who treat patients with breast cancer have known that tumors that develop resistance to chemotherapy are also more likely to grow larger and to spread, or metastasize, to other parts of the body.
Now a team of investigators from Memorial Sloan-Kettering has shown for the first time that these three phenomena — tumor growth, metastasis, and chemotherapy resistance — are connected to the same molecular changes inside breast cancer cells.
“The common link is a hormone that makes it easier for cancer cells to survive stress, whether it is the stress of chemotherapy or the stress of leaving their tumor of origin and trying to grow or establish themselves in another part of the body,” explains Joan Massagué, Chair of the Cancer Biology and Genetics Program in the Sloan-Kettering Institute and the senior author of the study, which was published July 6 in Cell. The study’s coauthors included Edi Brogi, Director of Breast Pathology, and Larry Norton, Deputy Physician-in-Chief for Breast Cancer Programs.
The findings also suggest that a new approach for developing treatments could make chemotherapy more effective, while at the same time preventing tumor growth and metastasis.
Studying Metastasis

Dr. Massagué’s laboratory has spent several years studying the genetic changes that allow breast cancer cells to survive and colonize in other parts of the body — such as the lungs, brain, and bones. In the current study, his team uncovered a mechanism that makes some breast cancer cells more resilient.
As they were analyzing the genes involved in metastasis, the researchers learned that two of them are genes called CXCL1 and CXCL2, which were already known to participate in inflammation, a natural response by which cells protect themselves from infection or injury.
“As the cancer cells spread and establish themselves in other parts of the body, they use the products from these genes to send out a signal that fools immune cells into protecting them and helping them survive,” Dr. Massagué explains. “And even more of this signal is sent out when cancer cells are exposed to chemotherapy.”
Finding Drugs to Target the Signal

“This research is important because it establishes a particular inflammation hormone as an important factor in the survival of cancer cells,” Dr. Massagué says. Because inflammation is a common problem in many different medical conditions, several classes of drugs already have been developed to address it.
In the paper, the investigators report that drugs designed to block the action of CXCL, which are currently in clinical trials for chronic inflammatory diseases, potentially could be useful as cancer therapies. The drugs were shown to shrink tumors and reduce metastasis to the lung in mouse models of breast cancer when used in combination with chemotherapy. These drugs made chemotherapy more effective at eliminating residual cancer cells in mice.

The researchers predict that, for patients, the greatest benefit of these drugs would likely be as a supplement to chemotherapy that is given as an additional treatment after surgery. “Eventually there may be other drugs that prove to be more effective,” Dr. Massagué concludes. “But this research establishes the principle that the genetic changes that make cancer cells aggressive have more consequences than we previously knew.”

This research was supported by the National Cancer Institute of the National Institutes of Health under award numbers CA94060 and CA163167. The investigators also received funding from the Howard Hughes Medical Institute, the Alan and Sandra Gerry Metastasis Research Initiative, and a Department of Defense Era of Hope breast cancer postdoctoral fellowship.

http://www.mskcc.org...rapy-resistance



Cancers now proven to develop resistance to chemotherapy resulting in further spread or recurrence post remission.

Therapies and adjuncts that inhibit resistance or do not develop resistance: Intravenous Vitamin C (sodium ascorbate), Gerson Therapy, and concentrated oil of Cannabidiol (cannabis). A lifestyle with dietary change to eliminate toxins and environmental contaminants is crucial to resolve root cause conditions.
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#6 froggymountain

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Posted 13 August 2012 - 06:20 PM

Hi froggyMountain, Hows it going for you?? I want to thank you for all of your helpful information that you always share with us,, I might not always agree, but isn't that what it's all about sometimes, We learn from each other, We are also able to get to know one another too,, and it's nice getting to know You...

The chemo and radiation scares the heck out of me,,I had known that the chemo and radiations was also killing the good cells, and I say it is about time that they are admitting it.. I have seen so much cancer around me here at home and on our GP site,, I have witnessed people put themselves through the chemo treatments right up till the end, They hang on to any hope there might be, big or small,, I say I don't understand but,, I also am not walking in their shoes,,, BLESSINGS TO THEM ALL!!!!

Peace, Happiness and always Good Health!!!!

Diversity is the beauty of all Nature.
GP are the best. It is a blessing finding you all.
You help me GROW - ;-)
I mean really grow inside.
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