Jump to content



                        Please Visit Our Paid Sponsors



Photo
- - - - -

Scientist Discover Drug To Replace Cannabis


  • Please log in to reply
8 replies to this topic

#1 DEBhasgrn

DEBhasgrn

    Still Searching

  • Seasoned Members
  • PipPipPipPipPipPipPip
  • 9058 posts
  • LocationMaine, USA

Posted 21 September 2010 - 11:18 AM

I found this article about what scientist have come up with now, a drug that activates the chemical in humans that relieves pain, They have made a drug to take the place of what Cannabis does for pain naturally.. This angers me, Why do they insist on keeping us on drugs that will cause side affects, I don't know of any drug that does not have some sort of side affect, do you? Why do they keep saying that Cannabis has it's many side affects while continuing to say this is why they must come up with something to replace what Cannabis is proven to do for our pain and so much more. Look at what they are trying to do, Look at the money being spent when the cure to many illnesses is right in front of them.

Here is the link to the article if you care to look at it. I find it disturbing..

http://www.redorbit....pain/index.html



Here is the article for those who might not be able to get the link to work...

Compound Boosts Marijuana-Like Chemical In The Body To Relieve Pain At Injury Site

Posted on: Monday, 20 September 2010, 22:35 CDT

Drug created by UCI, Italian team inhibits enzyme that breaks down anandamide

American and Italian researchers have found that a novel drug allows anandamide – a marijuana-like chemical in the body – to effectively control pain at the site of an injury.

Led by Daniele Piomelli, the Louise Turner Arnold Chair in Neurosciences and director of the Center for Drug Discovery at UC Irvine, the study suggests that such compounds could form the basis of pain medications that don’t produce sedation, addiction or other central nervous system side effects common with existing painkillers, such as opiates.

“These findings raise hope that the analgesic properties of marijuana can be harnessed to curb pain,” Piomelli said. “Marijuana itself is sometimes used in clinical settings for pain relief but causes many unwanted effects. However, specific drugs that amplify the actions of natural, marijuana-like chemicals are showing great promise.”

For the study, which appears in the Sept. 19 online version of Nature Neuroscience, rats and mice were given a drug created by Piomelli and colleagues at the Italian universities of Urbino and Parma. The researchers discovered that the compound, URB937, did not enter the central nervous system but simply boosted the levels of anandamide in peripheral tissues. Still, it produced a profound analgesic effect for both acute and chronic pain. This was surprising, since anandamide had been thought to only work in the brain.

The synthetic drug inhibits FAAH, an enzyme in the body that breaks down anandamide, dubbed “the bliss molecule” for its similarities to the active ingredient in marijuana. A neurotransmitter that’s part of the endocannabinoid system, anandamide has been shown in studies by Piomelli and others to play analgesic, antianxiety and antidepressant roles. It’s also important in regulating food consumption. Blocking FAAH activity enhances the effects of anandamide without generating the “high” seen with marijuana.

Piomelli and his team are now collaborating with drug discovery specialists at the Italian Institute of Technology, in Genoa, to develop the new compound – which is protected by a patent application – into a clinically useful medication.

Researchers from UCI, the University of Georgia, the University of Naples, the University of Parma, the University of Urbino and the Italian Institute of Technology participated in the study, which was supported by the National Institute on Drug Abuse and the Italian Ministry of Public Education
  • I8ntLucky_UR, Bueller, Itinkso and 2 others like this


                        Please Visit Our Paid Sponsors



#2 jangel

jangel

    Bridge Builder

  • Members
  • PipPipPipPipPipPipPip
  • 22352 posts

Posted 21 September 2010 - 12:17 PM

Deb, cannot get the link to load....might need a kick or some such.
  • I8ntLucky_UR, Bueller, Itinkso and 1 other like this

#3 DEBhasgrn

DEBhasgrn

    Still Searching

  • Seasoned Members
  • PipPipPipPipPipPipPip
  • 9058 posts
  • LocationMaine, USA

Posted 21 September 2010 - 12:28 PM

Deb, cannot get the link to load....might need a kick or some such.


Fixed it
  • jangel, I8ntLucky_UR, Bueller and 1 other like this

#4 artistickat

artistickat

    Happy Camper

  • Seasoned Members
  • PipPipPipPipPip
  • 752 posts

Posted 21 September 2010 - 12:50 PM

Deb: Big Pharma can't make money from MJ...they have to engineer a synthetic patentable version of it. Yes, it sickens me too.
  • jangel, I8ntLucky_UR, Itinkso and 1 other like this

#5 DragonTat2

DragonTat2

    Newbie

  • Seasoned Members
  • Pip
  • 15 posts
  • LocationPNW, USA

Posted 21 September 2010 - 12:59 PM

I

I found this article about what scientist have come up with now, a drug that activates the chemical in humans that relieves pain, They have made a drug to take the place of what Cannabis does for pain naturally.. This angers me, Why do they insist on keeping us on drugs that will cause side affects, I don't know of any drug that does not have some sort of side affect, do you? Why do they keep saying that Cannabis has many it's many side affects while continuing to say this is why they must come up with something to replace what Cannabis is proven to do for our pain and so much more. Look at what they are trying to do, Look at the money being spent when the cure to many illnesses is right in front of them.

Here is the link to the article if you care to look at it. I find it disturbing..

http://www.redorbit....pain/index.html


Good morning. Let's see where the brrright side might be in this.

I kinda like the part where it says, "a marijuana-like chemical in the body", allowing the layperson to begin to understand that we are all walking around with marijuana-like chemicals in our bodies. It's naturally occuring in everyone, except in some folks (us) it gets blocked somehow. So the fact that patients need *something* to get their own endocannabinoid system working is presented as fact. Yay. We *all* have an endocannabinoid system. (You should have seen the look on the woman's face outside my AA meeting when I explained to her about our endocannabinoid systems. Ha!)

If I edit this statement just a tad:
“These findings raise hope that the analgesic properties of marijuana can be harnessed to curb pain,” Piomelli said. “Marijuana itself is sometimes used in clinical settings for pain relief but causes many unwanted effects. However, specific drugs that amplify the actions of natural, marijuana-like chemicals are showing great promise.”
...
by taking out just the words but causes many unwanted effects, we find that cannabis *is* used in clinical settings! Also, it acknowledges the fact that we need to amplify our own natural, marijuana-like chemicals. Yay. Again.

I'm sure there's at least one other Yay! in the part about, "anandamide, dubbed “the bliss molecule” ", but that section is not written for a layperson in the least. At least this layperson.

Hope you're having an awesome day~

Edited by DragonTat2, 21 September 2010 - 01:02 PM.

  • I8ntLucky_UR, Bueller, Itinkso and 1 other like this

#6 DragonTat2

DragonTat2

    Newbie

  • Seasoned Members
  • Pip
  • 15 posts
  • LocationPNW, USA

Posted 21 September 2010 - 01:06 PM

Deb:

Big Pharma can't make money from MJ...they have to engineer a synthetic patentable version of it. Yes, it sickens me too.


From the article: "Piomelli and his team are now collaborating with drug discovery specialists at the Italian Institute of Technology, in Genoa, to develop the new compound – which is protected by a patent application – into a clinically useful medication."

$$$. Sigh...
  • I8ntLucky_UR, Bueller, Itinkso and 1 other like this

#7 playk328

playk328

    Seasoned Member

  • Banned
  • PipPip
  • 27 posts

Posted 15 January 2011 - 12:54 PM

There is no other drug out there that can do what cannabis does for the problems I have.. I would rather vape a plant that to pop a pill.

#8 DaGrapeApe

DaGrapeApe

    Educated Member

  • Seasoned Members
  • PipPip
  • 69 posts

Posted 15 January 2011 - 01:55 PM

It's all greed. Greed that sadly is slightly effective, has horrible side effects, and slowly kills you. But big pharma can't make money off a medicine that anyone with some dirt and lights can grow. In the end it will be legalized because government can eventually tax it. And Government greed is more powerful than big pharma greed (probably).
  • jangel, Itinkso and DEBhasgrn like this

#9 froggymountain

froggymountain

    SHeaven

  • Seasoned Members
  • PipPipPipPip
  • 369 posts
  • LocationDetroit

Posted 15 January 2011 - 03:06 PM

There are many issues in presenting manufactured compounds and chemicals to the human body. Solitary, isolated compounds, even from natural sources, generally cause even more problems than the target remedy supposes - especially from side effects. Natural enzymes, phytonutrients, minerals, flavonoids and a host of other trace elements accompany the main compound to provide a balanced efficacy. It is Nature’s balanced chemistry that provides healing. Some plant, botanical, extracts can by themselves be harmful or even poisonous. In short: cannabinoids or THC isolated from raw plant matter can be ineffective because they do not have the beneficial parts of the plant that facilitate metabolizing these key elements into the body. ALSO: Remember that light plant fractions (botanicals) are also temperature volatile – they break down at high temperatures: sometimes as low as 43degC (110degF). Therefore when you are medicating with herbal remedies a temperature under 57degC (135degF) is best. To attain this, a slow brewed tea or vaporizer can be utilized. Smoking exposes fragile botanicals to temperatures in excess of 204degC (400degF). The best method and application of herbal, botanical, remedies is extraction. Extraction should be done at a low temperature and with natural solvents (not petrochemicals – they are carcinogenic). The two best methods are ice and bubble bags (“hashish” method) - no chemicals here ;-) just pure, clean water OR ethanol (everclear).
  • Bueller, Lydia, Itinkso and 1 other like this




0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users