I would do a larger method of my current grow: Compact SOG in Coco. I would do 50 plants in rows of 5. One row would come out each week. I would probably use Gatorade bottles.

(The perfect thing would be something square, 4.8 inches on each side, or cylindrical with a diameter of 4.8 inches. Obviously I'm ignoring depth a little here, but 1 - 1.5 feet or so should work. Maybe more?)
Expected Yield: 1/4oz per plant. * 5 plants per week = 1 1/4oz per week * 10 weeks = 12 1/2 oz. = ~370g. And that should be on the low side. You can probably get up to 1g / watt this way if you're careful. This is based on the DrBud method which purports to get up to 2g / watt.
This requires a separate place for cloning though that can handle making 5 nice clones every week that are ready to start stretching. (Which means well rooted clones, probably with a few days of veg time. Too much veg time will give you either bushy plants or too tall plants.)
The downside is the 50 plants bit. I should ebb and flow it for real, right?

An ebb & flow with 4.8 in^2 rockwool cubes would probably work as well with less hassle when it comes time to water. Though I'm not sure what depth you could have on the rock wool. If 1.5 ft were possible, these would be some very big budded babies.
The other downside is this method probably runs afoul of most legal grows. But if that doesn't bother you, just make sure you keep no more than 99 plants in total...
And I guess it also becomes a hassle dealing with that many plants, giving them all space under the light. But oh well.